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Substances With this routine have a small opportunity for abuse relative to substances detailed in Routine IV and consist largely of preparations made up of minimal portions of sure narcotics.
^ S4 only if in drug combos; see #Legal standing. ^ Course C1 only for lower doses; see exemptions on Portaria SVS/MS 344/98. ^ Pharmacy drugs if acquired inside of a lower dose from the licensed pharmacy or in very low dose drug mix; see #Legal status.
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Suggestions launched because of the Medical Pharmacogenomics Implementation Consortium (CPIC) advise against administering codeine to ultrarapid metabolizers, where this genetic information and facts is out there. The CPIC also suggests that codeine use be prevented in bad metabolizers, resulting from its lack of efficacy in this team.[43]
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